Yes. For example, let's say your default TKLBAM backup is several gigabytes in size and you'd like to create a lighter 100 MB backup that will be updated more frequently and take less time to update/restore:

cp -a /etc/tklbam /etc/tklbam.light

echo -/var/www/\*/logs >> /etc/tklbam.light/overrides
echo -/home/liraz/bigfiles >> /etc/tklbam.light/overrides
echo -mysql:mydatabase/bigtable >> /etc/tklbam.light/overrides

export TKLBAM_CONF=/etc/tklbam.light

mkdir /var/lib/tklbam.light
export TKLBAM_REGISTRY=/var/lib/tklbam.light

tklbam-init
tklbam-backup

For convenience you may want to create a script that sets the TKLBAM_REGISTRY and TKLBAM_CONF environment variables:

cat > /usr/local/bin/tklbam-backup-light << EOF
#!/bin/bash
export TKLBAM_CONF=/etc/tklbam.light
export TKLBAM_REGISTRY=/var/lib/tklbam.light

tklbam-backup
EOF

chmod +x /usr/local/bin/tklbam-backup-light