Liraz Siri's picture

Probably the easiest way to set up multiple sites with TurnKey Drupal is to simply create another instance of the TurnKey Drupal appliance inside a virtual machine. Compartmentalizing a physical server using virtualization into multiple virtual machine is a great way to not only simplify deployment but also to make the most of your hardware while improving security (each instance will be isolated from the others).

Take a look at VMWare Server. It's free.