Pretty much anything, though storing backups to Amazon S3 is easiest because authentication and key management are automatic. You just need to run:
tklbam-backup
But you can also backup to any storage target supported by TKLBAM's back-end Duplicity including the local filesystem, NFS, Rsync, SSH, FTP, WebDAV, Rackspace CloudFiles and even IMAP.
The local filesystem is one of the easier storage targets to use because you don't need to mess around with authentication credentials.
So assuming you want to store your backup at /mnt/otherdisk: